Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry.
نویسندگان
چکیده
A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some of these compounds also inhibit telomerase at low micromolar concentration.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 128 50 شماره
صفحات -
تاریخ انتشار 2006